id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103029-nc5yf6x4	Wichmann, Stefan	Computational design of genes encoding completely overlapping protein domains: Influence of genetic code and taxonomic rank	2020-09-25		.txt	text/plain	8665	387	52	In this study the artificially designed sequences are compared to their original sequences in terms of amino acid identity, amino acid similarity, Hidden Markov Model profile and secondary structure in order to determine the impact of OLG construction and which sequences are potentially functional. While the previous study [30] tried to estimate an upper limit of how many domains can be successfully overlapped in at least one reading frame and position, here the average success rate for OLG construction is determined instead, which is more relevant in relation to both understanding constraints on the formation rate of naturally occuring OLGs and in assessing the likelihood of successful synthetic creation of OLGs. These results in one sense give an upper estimate of the ease of creating overlaps as the difficulty of obtaining an overlapping gene pair naturally is not directly addressed here.	./cache/cord-103029-nc5yf6x4.txt	./txt/cord-103029-nc5yf6x4.txt