id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103105-iqjksoim	Marinaik, Chandranaik B.	Programming Multifaceted Pulmonary T-Cell Immunity by Combination Adjuvants	2020-07-10		.txt	text/plain	7343	406	55	An acrylic acid-based adjuvant (ADJ), in combination with TLR agonists glucopyranosyl lipid adjuvant (GLA) or CpG promoted mucosal imprinting but engaged distinct transcription programs to drive different degrees of terminal differentiation and disparate polarization of TH1/TC1/TH17/TC17 effector/memory T cells. Further, these studies provided the first glimpse of the evolution of T-cell responses to adjuvanted vaccines in the lungs to define the quantitative, phenotypic and functional attributes of mucosal effector/memory CD8 and CD4 T cells that are associated with effective viral control in the lungs, and protection against H1N1 and H5N1 influenza infections. Studies to determine the transcriptional basis for the disparate differentiation of effector CD8 T cells in different adjuvant groups showed that the expressions of T-bet, IRF-4 and BATF were substantially greater in ADJ and ADJ+CpG groups, compared to GLA and ADJ+GLA groups ( Fig. 1D) .	./cache/cord-103105-iqjksoim.txt	./txt/cord-103105-iqjksoim.txt