id author title date pages extension mime words sentences flesch summary cache txt cord-103108-vmze2mdx Vanheer, Lotte Revealing the Key Regulators of Cell Identity in the Human Adult Pancreas 2020-09-25 .txt text/plain 7967 440 47 HIGHLIGHTS Reconstruction of gene regulatory networks for human adult pancreatic cell types An interactive resource to explore and visualize gene expression and regulatory states Predicting putative transcription factors driving pancreatic cell identity HEYL and JUND as candidate regulators of acinar and alpha cell identity, respectively Because TFs recognize DNA motifs in the genome, one can measure if inferred target genes are expressed within single cells, and therefore quantify the activity of TFs. Such approaches have revealed the regulatory programs in distinct systems including the Drosophila brain (Davie et al , 2018) , cancer (Wouters et al., 2020) , during early mouse embryonic development (Peng et al , 2019) , in a mouse cell atlas (Suo et al., 2018 ) and a human cell atlas (Han et al., 2020) . ./cache/cord-103108-vmze2mdx.txt ./txt/cord-103108-vmze2mdx.txt