id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103204-gt6upfri	Hölzer, Martin	PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection	2020-05-20		.txt	text/plain	1791	108	42	Summary PoSeiDon is an easy-to-use pipeline that helps researchers to find recombination events and sites under positive selection in protein-coding sequences. A comprehensive evolutionary analysis of significantly positively selected sites consist of several complicated steps, including (1) in-frame alignment; (2) Indel correction; (3) phylogenetic tree calculation; (4) selection of a best-fitting nucleotide substitution * To whom correspondence should be addressed. model; (5) detection of topological incongruence and breakpoint selection to describe putative recombination events; (6) calculation of positively selected sites (ω > 1) under varying models; (7) and their impact on the selective pressure acting on the whole alignment. PoSeiDon comprises an assembly of different scripts and tools ( Fig. 1) that allow for the detection of recombination and positive selection in protein-coding sequences. Here we present PoSeiDon, an easy-to-use Nextflow pipeline for the accurate detection of site-specific positive selection and recombination events in protein-coding sequences.	./cache/cord-103204-gt6upfri.txt	./txt/cord-103204-gt6upfri.txt