id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103343-k4v5ksvq	Naim, Nikki	NHR-49 Acts in Distinct Tissues to Promote Longevity versus Innate Immunity	2020-09-11		.txt	text/plain	823	62	54	title: NHR-49 Acts in Distinct Tissues to Promote Longevity versus Innate Immunity Aging and immunity are inextricably linked and many genes that extend lifespan also enhance immunoresistance. Here, we demonstrate that the Caenorhabditis elegans pro-longevity factor, NHR-49, also promotes resistance against Pseudomonas aeruginosa, but modulates immunity and longevity by spatially and mechanistically distinct mechanisms. NHR-49 expression is increased by germline ablation, an intervention that extends lifespan, but lowered by pathogen exposure. NHR-49 acted in multiple somatic tissues to promote longevity, whereas, it's pro-immunity function was mediated by neuronal expression. Thus, NHR-49 targets share the largest overlap with genes whose 182 In this study, we demonstrate that NHR-49 is a pro-longevity factor that modulates 368 lifespan and immunity through distinct mechanisms. In fertile, nhr-49 single 393 mutants, immunity was restored by presence in neurons or intestine, but lifespan 394 could be rescued from other tissues as well. elegans lifespan in a NHR-49/PPARalpha-dependent manner	./cache/cord-103343-k4v5ksvq.txt	./txt/cord-103343-k4v5ksvq.txt