id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103345-v555a2ll	Taylor, Adrian	The novel roles of choline transporter-like 1 and 2 in ethanolamine transport	2020-08-28		.txt	text/plain	3722	210	53	These data firmly established that CTL1 and CTL2 are the first identified ethanolamine transporters in the whole cells and mitochondria, with intrinsic roles in de novo PE synthesis by the CDP-Etn Kennedy pathway and compartmentation of intracellular ethanolamine. PC and PE are synthesized de novo by CDP-Cho and CDP-Etn branches of the Kennedy pathway in which the extracellular substrates choline (Cho) and ethanolamine (Etn) are actively transported into the cell, phosphorylated and coupled with diacylglycerols (DAG) to form the final phospholipid product. While multiple transport systems have been established for Cho, Etn transport is poorly characterized and there is no single gene/protein assigned a transport function for mammalian Etn. Cho transport for membrane phospholipid synthesis is mediated by Cho transporter like protein CTL1/SLC44A1 (3) . M1 and M2 cells only express CTL2 and at levels similar to Ctrl and Cos 7 cells, and do not have a functional CTL1 protein ( Fig. 2A,D) , strongly implicating CTL2 as responsible for the low affinity Etn transport.	./cache/cord-103345-v555a2ll.txt	./txt/cord-103345-v555a2ll.txt