id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103377-j1mmx7k7	Karasik, Agnes	Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences	2020-09-11		.txt	text/plain	11779	646	58	Since it was reported that RNase L activation increased translation of 3'UTR regions downstream of stop codons by interfering with factors that promote translation termination (eRF3) or ribosome recycling (ABCE1) (Le Roy et al., 2005) , we assessed the level of ribosome footprints in 3'UTRs. This level was assayed by computing the ratio of footprints in every 3'UTR relative to its respective main ORF within the coding sequence (density ratio, 3'UTR:ORF) for each transcript . The similarity in the effects suggests that translation of non-canonical regions occurs when RNase L is activated via naturally produced 2-5A from broad activation of the antiviral response by double-stranded RNAs. It should be noted that poly I:C treatment did result in slightly elevated 3'UTR ribosome footprints on some genes in a RNase L KO cell line (Supplemental Figure 4A ).	./cache/cord-103377-j1mmx7k7.txt	./txt/cord-103377-j1mmx7k7.txt