id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103462-z3d9lcar	Wang, Shiyu	CD4+ T cell subsets present stable relationships in their T cell receptor repertoires	2020-11-02		.txt	text/plain	2934	158	59	Here, we examined the features of TCR beta (TCRB) repertoire of the top clones within naïve, memory and regular T cell (Treg) subsets: repertoire structure, gene usage, length distribution and sequence composition. To unveil the influence of differentiation on TCR repertoire, we analyzed the sequencing 68 data of TCR beta (TCRB) chain of NT, ET, EMT, CMT, Tscm and Treg. It suggests 232 that the length distribution of TCRB repertoire of NT is highly skewed in these less-233 differentiated memory cells ( Figure 4B ). We detected the 320 relationships among the TCRB repertoire of top1000 clones of naïve, memory and Treg subsets 321 (including NT, ET, Tcm, Tem, Tscm ET and Treg) by estimating the repertoire structure, the 322 germline gene usage, the sequence composition (K-mer) and public CDR3 clone usage. In our study, public clones from NT are less maintained in 359 differentiated subsets, and SVM analyses indicate that sequence composition in memory 360	./cache/cord-103462-z3d9lcar.txt	./txt/cord-103462-z3d9lcar.txt