id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103502-asphso2s	Herrgårdh, Tilda	An organ-based multi-level model for glucose homeostasis: organ distributions, timing, and impact of blood flow	2020-10-21		.txt	text/plain	8160	409	60	Due to the involvement of numerous organs and sub-systems, each with their own intra-cellular control, we have developed a multi-level mathematical model, for glucose homeostasis, which integrates a variety of data. The final multi-level model describes >300 data points in >40 time-series and dose-response curves, resulting from a large variety of perturbations, describing both intra-cellular processes, organ fluxes, and whole-body meal responses. However, neither this model, nor any of the previously mentioned multi-level models, have subdivided the glucose uptake into the individual contributions of all of the main insulin-responding and glucose-utilizing organs: adipose tissue, muscle, and liver. The final combined model (Q4) can fit to all of the new data for glucose uptake in all organs (Fig 6) , as well as to all previous data, such as the postprandial glucose and insulin fluxes and concentrations in (Dalla Man et al.	./cache/cord-103502-asphso2s.txt	./txt/cord-103502-asphso2s.txt