id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103504-ucqqpra5	Zhang, Zhe	The conserved ER-transmembrane protein TMEM39 coordinates with COPII to promote collagen secretion and prevent ER stress	2020-09-20		.txt	text/plain	2877	184	55	From a genome-wide RNAi screen for 54 genes affecting ER stress response, we previously identified tmem-131 that defines a 55 broadly conserved family of proteins important for procollagen assembly and secretion 56 (22). RNAi knock-down of sec-23 and most other COPII genes 340 recapitulated the tmem-39 loss-of-function phenotypes in constitutively high ER stress 341 response, defective collagen secretion and sensitivity to osmolality stress in C. We also noticed that RNAi knock-down of many COPII related genes, such 343 as sec-23, sec-24.1, npp-20, sar-1, sec-12, rab-5 and trpp-8 caused more severe 344 phenotypes than tmem-39 RNAi, leading to lethality or developmental arrest that 345 prevent collagen phenotype analysis (Table 1) Recent work showed that TMEM39A facilitates the ER-to-Golgi transport of SAC1 and 355 regulates autophagosome formation (28). We found that RNAi knock-down of 356 autophagy related genes, such as sac-1 and let-363, caused autophagy induction but 357 did not affect the ER stress response or collagen secretion (Fig 6) .	./cache/cord-103504-ucqqpra5.txt	./txt/cord-103504-ucqqpra5.txt