id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103567-nh9i28lu	Vanachayangkul, Pattaraporn	Safety, pharmacokinetics, and liver-stage Plasmodium cynomolgi effect of high-dose ivermectin and chloroquine in Rhesus Macaques	2020-04-29		.txt	text/plain	3686	193	62	title: Safety, pharmacokinetics, and liver-stage Plasmodium cynomolgi effect of high-dose ivermectin and chloroquine in Rhesus Macaques Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (IC50 = 10.42 μM) and hypnozoites (IC50 = 29.24 μM) in primary macaque hepatocytes when administered in high-dose prophylactically but not when administered in radical cure mode. The safety, pharmacokinetics, and efficacy of oral ivermectin (0.3, 0.6, and 1.2 mg/kg) with and without chloroquine (10 mg/kg) administered for seven consecutive days was evaluated for prophylaxis or radical cure of Plasmodium cynomolgi liver-stages in Rhesus macaques. Approximately 3 weeks later, a second relapse occurred 174 in all negative control and ivermectin high-and low-dose treated macaques with no significant 175 differences for time to blood-stage parasitemia or treatment (Log-Rank (Mantel Cox) test P > 176 0.05). If a relapse occurs, 397 and blood-stage parasitemia reaches >5,000 parasites per µl, then macaques received seven 398 days of chloroquine (10mg/kg) plus ivermectin (1.2 mg/kg) for both the low-and high-dose 399 groups.	./cache/cord-103567-nh9i28lu.txt	./txt/cord-103567-nh9i28lu.txt