id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103592-lkngp2u6	Bachmaier, Kurt	Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury	2020-07-02		.txt	text/plain	6316	336	47	Using cecal ligation and puncture (CLP), a reproducible and clinically relevant mouse model of polymicrobial infection that causes ALI, we found that in naïve control mice after 2 sequential i.v. injections of ANP only ~4% of lung PMN endocytosed ANP as evidenced by ANP-specific fluorescence ( Figure 1B) . Importantly, we found that CCR1 receptor cell surface expression, consistent with the mRNA data, was significantly greater on lung ANP high PMN than in ANP low PMN before and 3h, 6h, and 12h after LPS stimulation ( Figure 3B ). We observed that nitrotyrosine-specific staining in inflammatory and parenchymal cells was significantly reduced in lungs and livers of mice treated with PANP when compared to ANP-treated controls ( Figure 6D ,E). Measuring a markers of overall cell damage, lactic dehydrogenase (LDH) (34) , revealed that the polymicrobial sepsis-induced increased serum activity of LDH was significantly reduced by PANP treatment when compared to ANP treated controls ( Figure 6G ).	./cache/cord-103592-lkngp2u6.txt	./txt/cord-103592-lkngp2u6.txt