id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103618-cl7evbr3	Wang, Yingxue	The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal respiratory infection by influenza A virus at epithelial surfaces	2020-05-07		.txt	text/plain	5685	324	51	Mice with systemic loss of non-canonical autophagy are exquisitely sensitive to low-pathogenicity murine-adapted IAV where extensive viral replication throughout the lungs, coupled with cytokine amplification mediated by plasmacytoid dendritic cells, leads to fulminant pneumonia, lung inflammation and high mortality. Mice with systemic loss of non-canonical autophagy are exquisitely sensitive to low-pathogenicity murine-adapted IAV where extensive viral replication throughout the lungs, coupled with cytokine amplification mediated by plasmacytoid dendritic cells, leads to fulminant pneumonia, lung inflammation and high Introduction Influenza A virus (IAV) is a respiratory pathogen of major global public health concern (Yamayoshi & Kawaoka, 2019). These mice, which lack non-canonical autophagy in phagocytic cells ( δWD mice infected with IAV appeared to be unable to resolve inflammatory responses resulting in sustained expression of pro-inflammatory cytokines, morbidity and 10 a striking lung pathology characterized by profuse migration of neutrophils into the airway at day 3 followed by macrophages on day 7.	./cache/cord-103618-cl7evbr3.txt	./txt/cord-103618-cl7evbr3.txt