id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103714-06hhlma3	Miller, Mariël	Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms	2020-06-04		.txt	text/plain	2440	146	51	In this study, an in vitro assessment was performed to determine the potential efficacy of a unique first-in-class series of antibiofilm antibiotics and compare outcomes to current clinical standards of care. The agent, CZ-01179, was formulated into a hydrogel and tested against mature biofilms of a clinical isolate of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa ATCC 27853 using two separate methods. Confocal imaging and staining indicated that CZ-01179 was 357 highly effective against well-established biofilms that were exposed to the formulated gel, 358 whereas clinical products had limited efficacy (Fig 5) . Outcomes indicated that of the clinical standards of care, gentamicin was most effective 366 against both monomicrobial and polymicrobial biofilms of MRSA and of P. CZ-01179 gels were more efficacious at 415 eradicating biofilms in all other cases when compared to the standard of care topicals in the 416 collagen tests (Fig. 6) .	./cache/cord-103714-06hhlma3.txt	./txt/cord-103714-06hhlma3.txt