id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103770-4svaq0at	Ogrodzinski, Martin P.	Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes	2019-10-07		.txt	text/plain	668	49	46	title: Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes Here, we used tumor-derived cell lines derived from the MMTV-Myc mouse model to investigate metabolic pathways that are differentially utilized between two subtypes of breast cancer. To determine metabolic profiles of histologically distinct mouse mammary tumor subtypes, 84 polar metabolites were extracted from tumor-derived cell lines and quantitated using LC-MS/MS. We found metabolites involved in several central carbon metabolic pathways to be differentially 86 abundant between EMT and papillary tumor-derived cell lines (Figure 2 ). In the EMT subtype, both oxidized and reduced forms of glutathione, a key metabolite in 88 redox homeostasis, are elevated ( Figure 2B ). Metabolites 92 increased in the papillary subtype include fructose bisphosphate (FBP; glycolysis); acetyl-CoA indicating relative metabolite differences between EMT and papillary tumor derived cell lines. (B) Representative bar graphs of metabolites with statistically significant differences between EMT and papillary subtypes.	./cache/cord-103770-4svaq0at.txt	./txt/cord-103770-4svaq0at.txt