id author title date pages extension mime words sentences flesch summary cache txt cord-103788-sxw4l9tt Talbot, Steven R. One score to rule them all: severity assessment in laboratory mice 2020-06-24 .txt text/plain 5994 345 56 Body weight, the Mouse Grimace Scale score, burrowing behavior, and the telemetry-derived parameters heart rate, heart rate variability, temperature, and general activity were used to investigate the quality of indicating severity during postoperative recovery. In addition to the data for 184 building the RELSA reference set from TM-implanted mice, we evaluated RELSA performance as a 185 tool for severity comparisons between models by including data from three additional animal studies 186 (colitis, stress, sepsis). To exclude selection bias, we calculated the models' severity level with a 285 full set of available variables: body weight change, burrowing behavior, MGS score and telemetry-286 derived parameters including hr, hrv and temperature. A RELSA score of 1 means that all contributing variables for a 584 test animal reached the same values as the largest observed deviations in the reference set with the 585 defined level of severity (here, "moderate"). ./cache/cord-103788-sxw4l9tt.txt ./txt/cord-103788-sxw4l9tt.txt