id author title date pages extension mime words sentences flesch summary cache txt cord-103812-ls6zgipi Norris, Rachael P. Gap junction internalization and processing in vivo: a 3D immuno-electron microscopy study 2020-06-30 .txt text/plain 4803 296 55 Less is understood about their internalization, which forms double membrane vesicles containing cytosol and membranes from another cell, called connexosomes or annular gap junctions. Gap junction internalization can also be considered to be a form of trogocytosis (Joly and Hudriser, 2003) in which a portion of the plasma membrane and cytosol of the neighboring cell is transferred to the engulfing cell (See Fig. 1A ). Serial sections were then imaged to obtain threedimensional information; this distinguished between internalized connexosomes and gap junctions in the process of invagination. In 7 of the 56 modified connexosomes, a patch of unlabeled outer membrane bulged outward from a labeled inner membrane ( suggesting that different types of vesicles were involved. Five serial sections through a modified connexosome containing several internal vesicles labeled with Cx43. ./cache/cord-103812-ls6zgipi.txt ./txt/cord-103812-ls6zgipi.txt