id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103864-4kec8re4	Miao, Zhen	Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets	2020-06-04		.txt	text/plain	1819	113	39	Here, we profiled open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. Mapping single nucleotide variants associated with human kidney disease identified critical cell types, developmental stages, genes, and regulatory mechanisms. Here, we reasoned that 474 single cell accessible chromatin information could be extremely useful to identify the cell type-475 specific enhancer regions and thereby the target cell type for the GWAS hits, however, such maps 476 have not been generated for the human kidney. 539 540 By performing massively parallel single cell profiling of chromatin state, we were able to define 541 the key regulatory logic for each kidney cell type by investigating cis-regulatory elements and TF-542 target gene interaction. 548 549 We also observed that the single cell open chromatin atlas was able to define more distinct cell 550 types even in the developing kidney compared to scRNA-seq analysis.	./cache/cord-103864-4kec8re4.txt	./txt/cord-103864-4kec8re4.txt