id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103868-iwpiti2h	Harrison, Angela R.	The Ebola virus interferon antagonist VP24 undergoes active nucleocytoplasmic trafficking	2020-08-11		.txt	text/plain	2255	124	45	Functions of the Ebola virus (EBOV) IFN antagonist VP24 include nucleocapsid assembly during cytoplasmic replication and inhibition of IFN-activated signalling by STAT1. Proteins of many viruses with cytoplasmic replication cycles similar to EBOV interact with the nuclear trafficking machinery, resulting in active nucleocytoplasmic shuttling important to immune evasion and other intranuclear functions. Thus, it appears that active In this study we have shown that EBOV VP24 undergoes active trafficking between the nucleus 275 and cytoplasm involving CRM1-dependent nuclear export via a NES at the VP24 C-terminus. Notably, the EBOV 287 matrix protein VP40 has also been reported to localise to the nucleus in infected and transfected 288 cells (16, 50); however, a direct role for active trafficking pathways to regulate localisation, 289 distinct from mechanisms such as diffusion or interaction with other host factors, has not been 290 defined.	./cache/cord-103868-iwpiti2h.txt	./txt/cord-103868-iwpiti2h.txt