id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103895-dt0ers70	Zeng, Xiangrui	Comparative Pathway Integrator: a framework of meta-analytic integration of multiple transcriptomic studies for consensual and differential pathway analysis	2018-10-16		.txt	text/plain	4508	269	54	Methods and Results We present a meta-analytic integration tool, Comparative Pathway Integrator (CPI), to address these issues using adaptively weighted Fisher's method to discover consensual and differential enrichment patterns, consensus clustering to reduce pathway redundancy, and a novel text mining algorithm to assist interpretation of the pathway clusters. In light of this, we proposed a framework of meta-analytical integration of multiple transcriptomic studies for consensual and differential pathway analysis, wrapped in a tool named Comparative Pathway Integrator (CPI). In order to identify both commonly and study-specifically enriched pathways, we applied the adaptively weighted Fisher's method [14] , which is originally developed to combine p-values from multiple genomic studies for detecting homogeneous and heterogeneous differentially expressed genes. In summary, CPI is a meta-analytic tool for discovering commonly expressed and study specific pattern in transcriptomic studies, that will also reduce pathway redundancy and conduct text mining to increase interpretability of the results.	./cache/cord-103895-dt0ers70.txt	./txt/cord-103895-dt0ers70.txt