id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-104030-eb29t38n	Morales-Nebreda, Luisa	Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia	2020-06-05		.txt	text/plain	3960	175	36	Using heterochronic (age-mismatched) adoptive Treg cell transfer experiments and molecular profiling in mice, we sought to determine whether the age-related impairment in repair following influenza-induced lung injury is intrinsic to Treg cells. Our data support a paradigm in which aged Treg cells fail to upregulate youthful reparative programs, activate maladaptive responses and consequently exhibit a cell-autonomous impairment in pro-recovery function, which delays resolution from viralinduced lung injury in aged hosts. Gene set enrichment analysis of these genes demonstrated that this methylation-regulated gene expression program was associated with pro-recovery processes and was significantly skewed toward young Treg cells ( Figure 6C) . Combined, these results show that age-related DNA methylation regulates the pro-reparative transcriptional regulatory network during recovery from influenza-induced lung injury. What are the molecular mechanisms underpinning the age-associated Treg cell gain or loss-of pro-reparative function in the lung following influenza infection?	./cache/cord-104030-eb29t38n.txt	./txt/cord-104030-eb29t38n.txt