id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-104036-790vk1cf	Liekkinen, Juho	Understanding the Functional Properties of Lipid Heterogeneity in Pulmonary Surfactant Monolayers at the Atomistic Level	2020-07-08		.txt	text/plain	6533	376	44	In this work, we combined all-atom molecular dynamics simulations, Langmuir trough measurements, and AFM imaging to study synthetic four-component lipid monolayers designed to model protein-free pulmonary surfactant. 22 It has been shown that the pulmonary surfactant monolayers and membranes exhibit phase behaviour that is believed to play roles in lung mechanics; tight packing of lipids with saturated lipid chains promotes its ability to lower surface tension, whereas lipids with unsaturated chains increase pulmonary surfactant fluidity and thus allow for its rapid adsorption to the air-water interface. By using our recently developed protocol for performing simulations of lipid monolayers at the air-water interface, 33, 46 we were able to reach quantitative agreement with experimental surface pressure-area isotherms. Plateau Surface pressure-area isotherm is a key quantity representing monolayer behavior at the water-air interface, and it is readily extracted from both Langmuir trough measurements and computer simulations.	./cache/cord-104036-790vk1cf.txt	./txt/cord-104036-790vk1cf.txt