id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-104162-fe51v2pt	Zhang, Chiyu	Potential Achilles heels of SARS-CoV-2 displayed by the base order-dependent component of RNA folding energy	2020-11-02		.txt	text/plain	3745	208	49	Although SARS-CoV-2 differs in many respects from HIV-1, the same technology displays regions with a high base order-dependent folding energy component, which are also highly conserved. While the regions are often also protein-encoding (e.g. NSP3, ORF3a), we suggest that their nucleic acid level functions – such as the ribosomal frameshifting element (FSE) that facilitates differential expression of 1a and 1ab polyproteins – can be considered potential "Achilles heels" for SARS-CoV-2, perhaps susceptible to therapies like those envisaged for AIDS. Assays of the base order-dependent component of the folding energy have shown that a highly conserved region, in otherwise rapidly mutating HIV-1 genomes, associates with an RNA structure corresponding, not to a protein-encoding function, but to an RNA packaging signal. This high GC% value can obscure the contribution of the base order-dependent component of the folding energy, which provides a sensitive indicator of local intraspecies pressures for the conservation of function within a population (i.e. a mutated organism is eliminated by natural selection so no longer can be assayed for function in the population).	./cache/cord-104162-fe51v2pt.txt	./txt/cord-104162-fe51v2pt.txt