id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260054-iihgc5nr	Cavallo, Luigi	D936Y and Other Mutations in the Fusion Core of the SARS-Cov-2 Spike Protein Heptad Repeat 1 Undermine the Post-Fusion Assembly	2020-06-08		.txt	text/plain	4062	210	59	3D structures are now available from the Protein Data Bank (PDB) (21) for the SARS-CoV-2 S protein in the pre-fusion conformation, also bound to the ACE2 receptor (22) (23) (24) (25) (26) (27) (28) , and for the post-fusion core of its S2 subunit in the postfusion conformation (29) . We downloaded all the SARS-CoV-2 genomic sequences from the GISAID resource on April 21 st 2020, extracted from them 7,692 complete S protein sequences and identified all the point mutations occurring in at least two identical sequences (see Methods). When looking at the post-fusion conformation of the SARS-CoV-2 spike protein S2 subunit, these mutations appear more revealing. Based on a thorough analysis of the S protein sequences, that we extracted from the genomic sequences of SARS-CoV-2 reported in GISAID on April 21 st , we identified the fusion core of the HR1 as a mutational hotspot.	./cache/cord-260054-iihgc5nr.txt	./txt/cord-260054-iihgc5nr.txt