id author title date pages extension mime words sentences flesch summary cache txt cord-260508-z11exbyu Wang, Hongru Synonymous mutations and the molecular evolution of SARS-Cov-2 origins 2020-10-12 .txt text/plain 4698 272 58 Phylogenetic analyses (Fig. 2 ) in genomic regions with all recombination tracts 6 (Supplementary Table 5 ) masked using Maximum-likelihood (Fig. 2a) and Neighbor-joining 7 based on synonymous (Fig. 2b ) or non-synoymous (Fig. 2c ) mutation distance metrics, 8 consistently support RmYN02 as the nearest outgroup to human SARS-CoV-2, in contrast to 9 previous analyses before the discovery of RmYN02, which instead found RaTG13 to be the 10 nearest outgroup ). Notice that the divergences 14 between human SARS-CoV-2 and the bat viral sequences, RaTG13 and RmYN02, in most 15 regions of the genome, are quite low compared to the other comparisons. While the overall divergence in the S gene encoding the spike protein could suggest the 10 presence of recombination in the region, previous study ) reported that the tree 11 based on synonymous substitutions supported RaTG13 as the sister taxon to the human SARS-12 ./cache/cord-260508-z11exbyu.txt ./txt/cord-260508-z11exbyu.txt