id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262958-tmp6yxlv	Pinto, Dora	Structural and functional analysis of a potent sarbecovirus neutralizing antibody	2020-04-09		.txt	text/plain	2241	147	55	The SARS-CoV-2 spike (S) glycoprotein 26 promotes entry into host cells and is the main target of neutralizing antibodies. None of the mAbs studied bound to 97 prefusion OC43 S or MERS-CoV S ectodomain trimers, indicating a lack of cross-98 reactivity outside the sarbecovirus subgenus (Extended Data Fig.1) . The structural data explain the S309 cross-reactivity between SARS-CoV-2 and 148 SARS-CoV as 19 out of 24 residues of the epitope are strictly conserved ( Fig. 2f and 149 Extended Data Fig. 6a To further investigate the mechanism of S309-mediated neutralization, we 175 compared side-by-side transduction of SARS-CoV-2-MLV in the presence of either 176 S309 Fab or S309 IgG. This analysis 208 identified at least four antigenic sites within the S B domain of SARS-CoV targeted by 209 our panel of mAbs. The receptor-binding motif, which is targeted by S230, S227 and 210 S110, is termed site I.	./cache/cord-262958-tmp6yxlv.txt	./txt/cord-262958-tmp6yxlv.txt