id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263594-jd9ako6c	Kang, Sisi	A COVID-19 antibody curbs SARS-CoV-2 nucleocapsid protein-induced complement hyper-activation	2020-09-11		.txt	text/plain	2517	181	56	Although human antibodies elicited by severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about the function of N-directed antibodies. Severe acute 57 respiratory distress syndrome-associated coronavirus-2 (SARS-CoV-2) nucleocapsid (N) protein 58 is a highly immunopathogenic and multifunctional viral protein (14) (15) (16) (17) (18) (19) , which elicited high titers 59 of binding antibodies in humoral immune responses (20) (21) (22) . Herein, 66 we report a human mAb derived from COVID-19 convalescent, with specific targeting to SARS-67 CoV-2 N protein and functionally compromising complement hyper-activation ex vivo. Isolation of N protein-directed mAbs 69 To profile antibody response to SARS-CoV-2 N protein in early recovered patients, we collected 70 six convalescent blood samples at seven to 25 days after the onset of the disease symptoms.	./cache/cord-263594-jd9ako6c.txt	./txt/cord-263594-jd9ako6c.txt