id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264919-0jlg2gkc	Hopp, Marie-Thérèse	Unravelling the debate on heme effects in COVID-19 infections	2020-06-12		.txt	text/plain	7093	366	49	On the one hand, we examine the possibility of a direct interaction of heme with select SARS-CoV-2 proteins and specific host cell proteins by applying our webserver HeMoQuest (Paul that is based on experimental data. One of the most promising findings was the prediction of heme-binding motifs (HBMs) in the host cell proteins ACE2 and TMPRSS2. We leveraged this multimodal information to hypothesize the pathways that connect key molecules associated with SARS-CoV-2 and heme to phenotypes observed in COVID-19 patients. Here, we have investigated the possibility of a direct interaction of heme with SARS-CoV-2 surface proteins and their human counterparts ACE2 and TMPRSS2. Apart from investigating the direct impact of heme on proteins at the interface of the virus-host cell interaction, we also explored similarities between relevant pathways characterizing the respective pathologies, i.e. labile heme occurrence in hemolytic conditions and COVID-19 disease progression ( Figure 4) .	./cache/cord-264919-0jlg2gkc.txt	./txt/cord-264919-0jlg2gkc.txt