id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265277-ymvrserl	Crooke, Stephen N.	Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome	2020-05-14		.txt	text/plain	4620	249	52	A final round of selection on the basis of HLA 197 promiscuity (i.e., predicted binding to > 3 HLA molecules) and predicted antigenicity scoring using the 198 VaxiJen 2.0 server produced a subset of five candidate peptides (four ORF1ab, one S protein) as potential 199 targets for vaccine development (Table 1) with the hypothesis that increased HLA binding promiscuity 200 meant broader population base coverage by those peptides. As selective pressures are known to introduce viral mutations that promote fitness and can lead 266 to evasion of immune responses (59, 60), we first sought to investigate the genetic similarity of all 267 reported SARS-CoV-2 clinical isolates and identify a consensus sequence for use in our epitope 268 prediction studies. An increasing number of studies have employed predictive algorithms to identify potential HLA 285 class I epitopes for SARS-CoV-2, although relatively few have comprehensively analyzed the entire viral 286 proteome.	./cache/cord-265277-ymvrserl.txt	./txt/cord-265277-ymvrserl.txt