id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267115-6jqdi417	Giobbe, Giovanni Giuseppe	SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids	2020-06-24		.txt	text/plain	8080	408	47	Collectively, we established the first expandable human gastric organoid culture across fetal developmental stages, and we support the hypothesis that fetal tissue seems to be less susceptible to SARS-CoV-2 infection, especially in early stages of development. Principal component analysis (PCA) showed smaller heterogeneity in the organoid groups derived at different stages of fetal and pediatric development with respect to the primary tissues analyzed at the same stages, which may also include some heterogeneity from the surrounding cells as a result of the isolation procedure (Fig. 3a) . In order to validate both fetal and pediatric gastric organoids as functional in vitro models of SARS-CoV-2 infection and replication, we optimized the culture condition for viral infection in a 3D system (Fig. 4a) .	./cache/cord-267115-6jqdi417.txt	./txt/cord-267115-6jqdi417.txt