id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268224-5tbb8df1	Di Gioacchino, Andrea	The heterogeneous landscape and early evolution of pathogen-associated CpG dinucleotides in SARS-CoV-2	2020-08-27		.txt	text/plain	7109	412	62	Using a model of the viral gene evolution under human host pressure, we find that synonymous mutations seem driven, in the N protein coding region, both by the viral codon bias and by the high value of the CpG content, leading to a loss in CpG. Finally we use a model of the viral gene evolution under human host pressure, characterized by the CpG force, to study synonymous mutations, and in particular those which change CpG content, observed since the SARS-CoV-2 entered the human population (Sec. 2.3). We first compute the global force on CpG dinucleotides for SARS-Cov-2 and a variety of other viruses from the Coronaviridae family affecting humans or other mammals (bat, pangolin), see Fig. 1a , using as null model the nucleotide usage calculated from human genome [22] (see Methods Sec. 4.2) 1 .	./cache/cord-268224-5tbb8df1.txt	./txt/cord-268224-5tbb8df1.txt