id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268339-jxm69ndw	Karamitros, Timokratis	SARS-CoV-2 exhibits intra-host genomic plasticity and low-frequency polymorphic quasispecies	2020-03-28		.txt	text/plain	3755	217	51	We analyzed NGS data derived from clinical samples of three Chinese patients infected with SARS-CoV-2, in order to identify smalland large-scale intra-host variations in the viral genome. The isolated SNVs and genomic rearrangements, reflect the intra-patient capacity of the polymorphic quasispecies, which may arise rapidly during the outbreak, allowing immunological escape of the virus, offering resistance to anti-viral drugs and affecting the sensitivity of the molecular diagnostics assays. Here, we explore intra-host genomic variants and low-frequency polymorphic quasispecies in Next Generation Sequencing (NGS) data derived from patients infected by SARS-CoV-2. The S1 subunit consists of a signal peptide and the NT and receptor binding (RB) domains, with the latter sharing only 40% amino acid identity with other SARS-related CoVs. Our analysis revealed that similarly to other genomic regions, the S1 subunit hosts many low-frequency SNVs, characterized by higher density compared to the rest of the S gene sequence (Figure 1-E) .	./cache/cord-268339-jxm69ndw.txt	./txt/cord-268339-jxm69ndw.txt