id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269285-2r40mico	Resnick, Samuel J.	A simplified cell-based assay to identify coronavirus 3CL protease inhibitors	2020-08-29		.txt	text/plain	1941	126	60	We describe a mammalian cell-based assay capable of identifying coronavirus 3CL protease (3CLpro) inhibitors without requiring the use of live virus. In general, we observe concordance between compounds showing activity within 129 this transfection-based 3CL assay and live virus studies ( Supplementary Fig. 4a -e) 13 . The other hit from the 169 screen, GRL-0496, shares structural similarity to several other compounds within the library, one of 170 which is a previously reported 3CLpro inhibitor (MAC-5576) that failed to show activity against 5.05 µM against SARS-CoV-2 3CLpro within our transfection-based assay (Fig. 4c ). . https://doi.org/10.1101/2020.08.29.272864 doi: bioRxiv preprint we propose that this cellular protease assay system could be industrialized to screen and optimize a 219 large number of compounds to discover potential treatments for future viral pandemics.	./cache/cord-269285-2r40mico.txt	./txt/cord-269285-2r40mico.txt