id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270698-9w3ap3gz	Guo, Hua	Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes	2020-05-13		.txt	text/plain	2496	142	59	title: Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes The Chinese horseshoe bat (Rhinolophus sinicus), reservoir host of severe acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs (SARSr-CoVs) with high genetic diversity, particularly in the spike gene. Despite these variations, some bat SARSr-CoVs can utilize the orthologs of human SARS-CoV receptor, angiotensin-converting enzyme 2 (ACE2), for entry. Consistent results were observed by binding affinity assays between SARSand SARSr-CoV spike proteins and receptor molecules from bats and humans. In a host-virus arms race situation, the genes involved tend to display dN/dS ratios Codon-based analysis of molecular evolution 536 Bat ACE2 and SARSr-CoV spike sequences were analyzed for positive selection. Identification of key amino acid 671 residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a 672 receptor for severe acute respiratory syndrome coronavirus	./cache/cord-270698-9w3ap3gz.txt	./txt/cord-270698-9w3ap3gz.txt