id author title date pages extension mime words sentences flesch summary cache txt cord-270919-0hldozml Cortey, Martí SARS-CoV-2 amino acid substitutions widely spread in the human population are mainly located in highly conserved segments of the structural proteins 2020-05-17 .txt text/plain 1063 73 56 title: SARS-CoV-2 amino acid substitutions widely spread in the human population are mainly located in highly conserved segments of the structural proteins The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic offers a unique opportunity to study the introduction and evolution of a pathogen into a completely naïve human population. At the moment of writing this paper, these mutations present a varied success in the SARS-CoV-2 virus population; ranging from a change in the spike protein that becomes absolutely prevalent, two mutations in the nucleocapsid protein showing frequencies around 25%, to a mutation in the matrix protein that nearly fades out after reaching a frequency of 20%. 54 The aim of the present study was to determine the amino acid substitutions in viral 55 proteins that were widely present in available sequences of SARS-CoV-2, relating them 56 to the known chronology of the pandemic. ./cache/cord-270919-0hldozml.txt ./txt/cord-270919-0hldozml.txt