id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272626-bw9lbzvt	Pizzorno, Andrés	Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia	2020-04-02		.txt	text/plain	2051	116	40	Here, we advantageously used human reconstituted airway epithelial models of nasal or bronchial origin to characterize viral infection kinetics, tissue-level remodeling of the cellular ultrastructure and transcriptional immune signatures induced by SARS-CoV-2. Developed from biopsies of nasal or bronchial cells differentiated in the air/liquid interphase, these models reproduce with high fidelity most of the main structural, functional and innate immune features of the human respiratory epithelium that play a central role 70 in the early stages of infection and constitute robust surrogates to study airway disease mechanisms and for drug discovery (10) . Comparably, daily treatment with 20 µM remdesivir resulted in 7.3 log10 and 7.9 log10 reductions of intracellular SARS-CoV-2 viral titers at 48 hpi in nasal and bronchial HAE, respectively (Fig. 4D, upper panel) .	./cache/cord-272626-bw9lbzvt.txt	./txt/cord-272626-bw9lbzvt.txt