id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273645-czh3zfb3	Lu, Shuaiyao	Comparison of SARS-CoV-2 infections among 3 species of non-human primates	2020-07-17		.txt	text/plain	2197	171	65	In this study, two families of non-human primates, Old world monkeys (12 Macaca mulatta, 6 Macaca fascicularis) and New world monkeys (6 Callithrix jacchus), were experimentally inoculated with SARS-CoV-2. Here, to establish the COVID-19 model, two families including 3 species of non-human primates, which are widely used for animal models with their own advantages and disadvantages, were experimentally infected with SARS-CoV-2, followed by comparisons of clinical symptoms, hematology, biochemical indexes, immunology and histopathology among 3 species. Given that host factors may be involved in viral pathogenesis, we designed an experiment in the present study to investigate whether host genetics, age and gender affect SARS-CoV-2 infection in non-human primates ( Figure 1 ). To know dynamics of viral replication and virus shedding, samples of nasal swabs, throat swabs, anal swabs, feces, blood and tissues were collected at the indicated time points, and SARS-CoV-2 genomes were quantitated by RT-qPCR.	./cache/cord-273645-czh3zfb3.txt	./txt/cord-273645-czh3zfb3.txt