id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275252-4e3cn50u	Rad SM, Ali Hosseini	Implications of SARS-CoV-2 mutations for genomic RNA structure and host microRNA targeting	2020-05-16		.txt	text/plain	4368	302	53	In addition to amino acid changes, mutations could affect RNA secondary structure critical to viral life cycle, or interfere with sequences targeted by host miRNAs. We have analysed subsets of genomes from SARS-CoV-2 isolates from around the globe and show that several mutations introduce changes in Watson-Crick pairing, with resultant changes in predicted secondary structure. The impact of these and further mutations on secondary structures, miRNA targets or potential splice sites offers a new context in which to view future SARS-CoV-2 evolution, and a potential platform for engineered viral attenuation and antigen presentation. A common primary focus of mutational analysis of emerging viruses is the alteration in amino acid sequence of viral proteins that may provide enhanced or new functions for virus replication, immune avoidance, or spread. However, the potential of these mutations to impact upon RNA structure and miRNA recognition provides a basis for ongoing monitoring of viral evolution at these sites in the SARS-CoV-2 genome.	./cache/cord-275252-4e3cn50u.txt	./txt/cord-275252-4e3cn50u.txt