id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276017-2375ipkk	Chen, Dongsheng	Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife	2020-06-14		.txt	text/plain	4132	365	70	Notably, the proportion of SARS-CoV-2 target cells in cat was found considerably higher than other species we investigated and SARS-CoV-2 target cells were detected in multiple cell types of domestic pig, implying the necessity to carefully evaluate the risk of cats during the current COVID-19 pandemic and keep pigs under surveillance for the possibility of becoming intermediate hosts in future coronavirus outbreak. Previous studies have proposed that animal tissues show high heterogeneity in terms of cellular composition and gene expression profiles 15 , and ACE2 is only expressed in a small proportion of specific cell populations 16 , making single cell analysis of SARS-CoV-2 target cells an attracting field to investigate. Here, we constructed the single cell atlas for livestock, poultry, pets and wildlife, then screened putative SARS-CoV-2 target cells (indicated by the co-expression patterns of SARS-CoV-2 entry receptor ACE2 and SARS-CoV-2 entry activator TMPRSS2) and systematically evaluated their susceptibility, with the aim to understand the virus transmission routes and provide clues to fight against COVID-19.	./cache/cord-276017-2375ipkk.txt	./txt/cord-276017-2375ipkk.txt