id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277648-9kxwkcbl	Overholt, Kalon J.	Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution	2020-06-19		.txt	text/plain	10003	421	39	Bulk RNA sequencing (bulk RNA-seq) and single-cell RNA sequencing (scRNA-seq) studies have identified stark transcriptional differences between bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cell (PBMC) samples in hospitalized COVID-19 patients, indicating that immunological responses may be highly compartment-specific [21, 22] . We used identical methods to separately analyze multi-donor scRNA-seq datasets from bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMCs) in COVID-19 patients classified by severity strata as well as healthy control subjects to investigate severity-specific immune dysregulation in the lung and periphery. When we increased this analysis to include all of the cell types found in the BALF (Figure 3A We next investigated pathway-level changes occurring in PBMCs and found that differential gene expression between ARDS and non-ARDS patients supported the detection of statistically enriched pathways through GSEA.	./cache/cord-277648-9kxwkcbl.txt	./txt/cord-277648-9kxwkcbl.txt