id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280025-4hmecfi0	Korber, B	Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2	2020-05-05		.txt	text/plain	11173	524	54	We have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-CoV-2, focusing initially on the Spike (S) protein because it mediates infection of human cells and is the target of most vaccine strategies and antibody-based therapeutics. Over the past two months, the HIV database team at Los Alamos National Laboratory has turned to developing an analysis pipeline to track in real time the evolution of the SARS-CoV-2 Spike (S) protein in the COVID-19 pandemic, using the Global Initiative for Sharing All Influenza Data GISAID SARS-CoV-2 sequence database as our baseline (Sup. Item 1 is the GISAID acknowledgments table, listing all the groups who contribute sequences to this global effort) (Elbe and Buckland-Merrett, 2017; Shu and McCauley, 2017) . GISAID is the primary SARS-CoV-2 sequence database resource, and our intent is to complement what they provide with visualizations and summary data specifically intended to support the immunology and vaccine communities, and to alert the broader community to changes in frequency of mutations that might signal positive selection and a change in either viral phenotype or antigenicity.	./cache/cord-280025-4hmecfi0.txt	./txt/cord-280025-4hmecfi0.txt