id author title date pages extension mime words sentences flesch summary cache txt cord-280922-w6a5ec06 Sen, Sanjana Predicting COVID-19 Severity with a Specific Nucleocapsid Antibody plus Disease Risk Factor Score 2020-10-29 .txt text/plain 4134 289 55 Here, ELISA and coronavirus antigen microarray (COVAM) analysis mapped antibody epitopes in the plasma of COVID-19 patients (n = 86) experiencing a wide-range of disease states. Here, ELISA and coronavirus antigen microarray (COVAM) analysis mapped antibody epitopes in the plasma of COVID-19 patients (n = 86) experiencing a wide-range of disease states. Furthermore, a recent review on antibody-dependent enhancement of SARS-CoV-2 stated, "At present, there are no known clinical findings, immunological assays or biomarkers that can differentiate any severe infection from immune-enhanced disease, whether by measuring antibodies, T cells or intrinsic host responses (7) ." This conclusion inspired our study. The results demonstrate that Abs to a specific epitope from N protein plus disease risk factors strongly correlate with COVID-19 disease severity. The DRFS of patients with αEp9 Abs strongly correlates with COVID-19 disease severity (Pearson's r = 0.72, p-value <0.0001, and R 2 = 0.52) (Fig. 4A) . ./cache/cord-280922-w6a5ec06.txt ./txt/cord-280922-w6a5ec06.txt