id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281565-v8s2ski3	Belmonte-Reche, Efres	Exploring G and C-quadruplex structures as potential targets against the severe acute respiratory syndrome coronavirus 2	2020-08-20		.txt	text/plain	4545	253	53	These PQS and PiMS have been assessed according to their potential to form, uniqueness, frequency of appearance, conservation rates between 3297 different 2019-nCoV clinical cases, confirmed quadruplex-forming sequence presence and localization within the genome. Then, these PQS and PiMS were evaluated by their frequency of appearance in the corresponding genome, the presence of known-to-form quadruplex structures sequences within and their probability of quadruplex-formation score (as the mean of G4Hunter (52) and the adaptation of the PQSfinder algorithm (53) ). A flexible configuration of quadruplex definitions will detect larger amounts of candidates at the expense of requiring more computing power and accepting sequences that are more ambiguous in forming quadruplex structures in vitro (as determined by their score; with longer loops, smaller runs, more bulges and more complementary G/C %, Figure 1 , B). Expanding the search for common candidates to the entire virus realm, we matched one PQS and PiMS from the 2019-nCoV with the potential quadruplexes found in four viruses from	./cache/cord-281565-v8s2ski3.txt	./txt/cord-281565-v8s2ski3.txt