id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281717-kzd9vvci	Digard, Paul	Intra-genome variability in the dinucleotide composition of SARS-CoV-2	2020-05-08		.txt	text/plain	4473	266	53	CpG dinucleotides are under-represented in the genomes of single stranded RNA viruses, and coronaviruses, including SARS-CoV-2, are no exception to this. CpG suppression amongst coronaviruses does not significantly differ according to genera of virus, but does vary according to host species and primary replication site (a proxy for tissue tropism), supporting the hypothesis that viral CpG content may influence cross-species transmission. 79 SARS-CoV-2 was recently reported to have a CpG composition lower than other members of the 80 betacoronavirus genus, comparable to certain canine alphacoronaviruses; an observation used to draw 81 inferences over its origin and/or epizootic potential (Xia 2020 in GC content (from ~ 0.32 -0.47) was seen across the Coronaviridae, and as expected, all viruses 97 exhibited some degree of CpG suppression, with CpG O:E ratios ranging from 0.37 to 0.74 (Fig 2A) .	./cache/cord-281717-kzd9vvci.txt	./txt/cord-281717-kzd9vvci.txt