id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284068-sbon3aes	Mok, Chee Keng	Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis	2020-06-22		.txt	text/plain	1798	104	49	Validation assays to determine changes in infectious virus titres upon treatment was carried out by testing selected hit compounds in dose-dependent assays in Vero E6 to confirm the primary screen observation and also in the human hepatocarcinoma HuH7 cell line as the latter cell line expresses high levels of the ACE2 receptor (10) and supports replication of coronaviruses (11) . While recent data has shown that vitamin D levels are negatively associated with morbidity and mortality of COVID-19 cases (13, 14) , this is the first report of a direct inhibitory effect of calcitriol on SARS-CoV-2. The authors speculated that vitamin D supplementation could protect against SARS-CoV-2 infection and improve patient disease outcomes (16) , and our finding certainly provides credence to this hypothesis. Given the high transmissibility of SARS-CoV-2 globally (23), if these findings can be replicated in clinical trials, calcitriol may certainly prove to be an effective tool in the effort to control the pandemic while waiting for an effective vaccine to be rolled out globally.	./cache/cord-284068-sbon3aes.txt	./txt/cord-284068-sbon3aes.txt