id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284191-05djnz4p	Bert, Nina Le	Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals	2020-05-27		.txt	text/plain	1944	103	53	To study SARS-CoV-2 specific T cells associated with viral clearance, we collected peripheral blood of 24 individuals who recovered from mild to severe COVID-19 (demographic, clinical and virological information are summarized in Extended Data Table 1 ) and studied the T cell response against selected structural (nucleocapsid protein-NP) and non-structural proteins (NSP7 and NSP13 of ORF1) of the large SARS-CoV-2 proteome ( Figure 1A) . To confirm and further delineate the multispecificity of the NP-specific T cell response detected ex vivo in COVID-19 recovered patients, we defined in nine individuals, the distinctive sections of NP targeted by T cells. This is consistent with the findings of Grifoni et al 11 : using selected peptides, they detected ORF-1 specific T preferentially in some SARS-CoV-2 unexposed donors while T cells of COVID-19 recovered donors preferentially recognized structural proteins. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals	./cache/cord-284191-05djnz4p.txt	./txt/cord-284191-05djnz4p.txt