id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287172-h8zoplkm	Ghobrial, Moheb	The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors	2020-10-21		.txt	text/plain	7020	315	55	To understand the potential mechanisms underlying SARS-CoV-2 tropism for brain vasculature, we constructed a molecular atlas of the expression patterns of SARS-CoV-2 viral entry-associated genes (receptors and proteases) and SARS-CoV-2 interaction partners in human (and mouse) adult and fetal brain as well as in multiple non-CNS tissues in single-cell RNA-sequencing data across various datasets. Notably, the top regulated pathways included inflammation, angiogenesis, coagulation, cell-extracellular matrix interaction, viral-host interaction, vascular metabolism, blood-brain-barrier permeability, and reactive oxygen species (ROS) in both the adult and the fetal brain endothelium ( Together, these data reveal that CTSB is highly expressed in various endothelial cell clusters of the fetal and adult human brain and that pathways downstream of CTSB might provide a suggestive explanation of some of the neurovascular symptoms observed in COVID-19	./cache/cord-287172-h8zoplkm.txt	./txt/cord-287172-h8zoplkm.txt