id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287372-ya5uvoki	Böszörményi, Kinga P.	Comparison of SARS-CoV-2 infection in two non-human primate species: rhesus and cynomolgus macaques	2020-11-05		.txt	text/plain	3973	249	58	This study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque models and suggests that both species represent an equally good model in research for both COVID-19 prophylactic and therapeutic treatments. Rhesus macaques have also been applied 116 in COVID-19 pathogenesis studies [22, 24, 32, 33] , and to test the efficacy of remdesivir in the 117 treatment of SARS-CoV-2 infection [34] . we compared SARS-CoV-2 replication in rhesus and cynomolgus macaque species and 129 monitored signs of COVID-19-like disease symptoms for three weeks after infection. The animals from this study were not 342 euthanized to be able to perform re-infection studies or to monitor them for late clinical signs, 343 or co-morbidities related to We conclude that the course of SARS-CoV-2 infection of both macaque species is highly 345 similar, indicating that they are equally suitable models to test vaccines and antivirals in a 346 preclinical setting for safety and efficacy.	./cache/cord-287372-ya5uvoki.txt	./txt/cord-287372-ya5uvoki.txt