id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292670-12prczym	Urra, José Miguel	The antibody response to the glycan α-Gal correlates with COVID-19 disease symptoms	2020-07-14		.txt	text/plain	2099	115	44	Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response against pathogenic viruses and other microorganisms containing this modification on membrane proteins mediated by anti-α-Gal IgM/IgG antibodies produced in response to bacterial microbiota. These results support the proposal of developing interventions such as probiotics based on commensal bacteria with α-Gal epitopes to modify the microbiota and increase the α-Gal-induced protective immune response and reduce the severity of COVID-19. Although more severe symptoms have been associated with elderly patients, herein older 199 patients were recorded in the hospitalized and not the ICU group (p < 0.001; Table 1 The serum IgA, IgE, IgM and IgG antibody response to α-Gal was characterized in healthy 226 individuals and COVID-19 patients at different disease stages (Figures 2 and 3a) .	./cache/cord-292670-12prczym.txt	./txt/cord-292670-12prczym.txt