id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293428-8hj06hzt	Yang, Jianling	Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model	2020-04-24		.txt	text/plain	1855	88	53	To further uncover the toxicity profile of CQ and HCQ in different tissues, we evaluated the cytotoxicity of them in 8 cell lines, and further adopted the physiologically-based pharmacokinetic models (PBPK) to predict the tissue risk respectively. HCQ has the less impact in 7 cell lines proliferation and less toxicity compared to CQ in heart, liver, kidney and lung. Recent 99 publications have demonstrated that chloroquine (CQ) and hydroxychloroquine (HCQ) 100 efficiently inhibited SARS-CoV-2 infection in vitro assay (7-9). The data suggest that HCQ was 127 demonstrated to be much less toxic than CQ, at least at certain key tissues (heart, liver, 128 kidney, and lung). However, the tissue trough concentration of 197 HCQ in lung is the highest level (25.633 μg/ml) compared with liver, kidney and heart 198 (Table 2 and Figure 4 ). Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting 286 SARS-CoV-2 infection in vitro	./cache/cord-293428-8hj06hzt.txt	./txt/cord-293428-8hj06hzt.txt